The different mechanisms through which immune tolerance to antigens can occur, and their relative importance in preventing the development of allergic disease

Scientific Essay , 2014 , 24 Pages , Grade: 1st

Medicine - Anatomy, Physiology, Cytology

Immune tolerance is the inhibition or absence of an immune response leaving only protective and beneficial immunity intact. Tolerance reduces response to both self and non-self antigens, which are substances which stimulate antibody production.
Tolerance breakdown causes immune disease; failed self-tolerance causes incorrect identification of self as foreign, causing autoimmune disease. Failure of induced tolerance causes overzealous identification of harmless foreign substances as a threat, causing hypersensitivities.

This essay explores the immunological mechanisms by which tolerance occurs, and their role in preventing the development of allergic disease.

Table of Contents

Allergy

Central Tolerance
T-cell tolerance
B-cell Tolerance

Peripheral Tolerance
Anergy
Deletion
B cell antibody production

Immune Deviation

Regulatory Lymphocytes
Regulatory T cells: Treg, Tr1, Th3
Regulatory B cells: Breg, Br1, Br3

Innate Immune System: Dendritic cells

Immune Privilege

Tolerance in Pregnancy

Induced Tolerance

Conclusion

References

• College: Imperial College London
• Grade: 1st
• Author: Charlotte Leahy (Author)
• Publication Year: 2014
• Pages: 24
• Catalog Number: V352611
• ISBN (eBook): 9783668390508
• ISBN (Book): 9783668390515
• Language: English