It is generally assumed that human beings have personalities, while animals do not. This assumption is not only derived from common sense, but also a basic principle of western philosophy and social theory (Mead, 1934). Still, dog owners will not stop mumbling about their cute puppy's unique personality. And they find support from unexpected source: Biologists argue that humans are nothing more, nothing less than animals. So they, too, begin to take into consideration that animals – including humans – might have a personality. What seems like a solely philosophical question at first glance, has important practical impacts, because the existence of animal personality contradicts the assumption that animals used in biological experiments can be standardized, and have uniform properties. If despite all efforts of standardization a residual variation cannot be eliminated, pharmaceutical and medical experiments might lose part of their validity.
Therefore the hypothesis that laboratory mice possess a personality was tested in an empirical study. In this study a set of standard behavior tests was performed with 40 female mice of the strain C57BL/6N. The data was then analyzed for correlations over time and across contexts, since this is a requirement for animal personality.
Table of Contents
Table of Contents
Table of figures and tables
Abbreviations
1. Introduction
1.1 Definition
1.2 State of the Art
1.3 Standardization
1.4 Hypotheses
2. Animals, Material, and Methods
2.1 Animals, housing, and experimental conditions
2.2 Behavioral tests
2.3 Experimental Design
2.3.1 The Elevated Plus Maze (EPM)
2.3.2 The Open Field Test (OF)
2.3.3 The Object Exploration Test (OBX)
2.3.4 The Social Investigation Test (SI)
2.3.5 The Dark/Light Test (DL)
2.3.6 The Free Exploration Task (FET)
2.4 Videos and computer software
2.4.1 VirtualDub
2.4.2 Optimas
2.4.3 Tracking Analysis
2.4.4 Statistical analysis
3. Results
3.1 Correlations over time
3.1.1 The Elevated Plus Maze (EPM)
3.1.2 The Open Field Test (OF)
3.1.3 The Object Exploration Test (OBX)
3.1.4 The Social Investigation Test (SI)
3.1.5 The Dark/Light Test (DL)
3.1.6 The Free Exploration Task (FET)
3.2 Correlation across contexts
3.2.1 The Elevated Plus Maze (EPM)
3.2.2 The Open Field Test (OF)
3.2.3 The Object Exploration Test (OBX)
3.2.4 The Social Investigation Test (SI)
3.2.5 The Dark/Light Test (DL)
3.2.6 The Free Exploration Task (FET)
3.3 Differences between individuals
4. Discussion
4.1 Correlation over time
4.2 Correlation across contexts
4.3 Differences between individuals
4.4 Implications
5. Conclusion
6. References
7. Acknowledgements
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