The contribution brings together our most recent papers, dealing with stochastic dynamics mass spectrometry, the first of which is written specially for this book. It can be regarded as introductory review-chapter, which represents, in fact, an overview of contributions devoted to methodological development of quantitative and structural stochastic dynamics mass spectrometric approaches to soft-ionization methods.
The books are primarily intended for widespread use of graduated students, who after the first introductory Chapter 1 to the field of stochastic dynamics soft-ionization quantitative and 3D structural mass spectrometry may wish to deepen their knowledge of primary application of model formulas to hard-ionization approaches. Of course, we hope that it shall be useful not only to undergraduate student, but also to both junior and senior academics and researchers in the analytical mass spectrometry. Owing to the fact, that analytical mass spectrometry is robust method for quantitative and structural analysis, amongst others, not only for fundamental science and a lot of specific scientific disciplines, but also to the industry, the book is designed to serve major and specific goals of both science and various branches of the industry.
Table of Contents
- CHAPTER 1
- INTRODUCTION
- QUANTITATIVE MASS SPECTROMETRY – AN OVERVIEW
- Theoretical concepts of quantifying analytes mass spectrometrically
- Quantitative mass spectrometric analysis of pharmaceutics and compounds suspecting to cause adverse health effects to humans
- STRUCTURAL MASS SPECTROMETRY – AN OVERVIEW
- STOCHASTIC DYNAMIC MASS SPECTROMETRIC THEORY
- Formalism of the stochastic dynamic theory
- Application of the stochastic dynamic mass spectrometric theory
- Stochastic dynamic mass spectrometric quantitative analysis in condensed phases
- Stochastic dynamic mass spectrometric 3D molecular structural analysis
- Calculation of quantum chemical diffusion parameters according to Arrhenius's model equation
- Correlation between theory and experiment
- CONCLUSION
- REFERENCES
- CHAPTER 2
- INTRODUCTION
- EXPERIMENTAL
- Materials and methods
- Chemometrics
- RESULTS
- DISCUSSION
- CONCLUSION
- REFERENCES
Objectives and Key Themes
The objective of this work is to present a unified approach to quantitative and structural analysis using mass spectrometry, encompassing both soft and hard ionization methods. This is achieved through the application of stochastic dynamic theory and its associated model equations. The book aims to bridge the gap between different mass spectrometry techniques and make advanced methodologies accessible to a wider audience.
- Stochastic dynamic mass spectrometric theory and its applications.
- Quantitative analysis of analytes in various matrices using mass spectrometry.
- Determination of 3D molecular and electronic structures via mass spectrometry.
- Application of stochastic dynamics to both soft and hard ionization mass spectrometry.
- Bridging the gap between soft and hard ionization techniques in quantitative and structural mass spectrometry.
Chapter Summaries
CHAPTER 1: Stochastic dynamics soft-ionization mass spectrometric method for quantitative and 3D structural analyses - a review-chapter. This chapter serves as an introductory review, providing an overview of quantitative and structural stochastic dynamics mass spectrometric approaches, primarily focusing on soft ionization methods. It details the theoretical concepts behind quantifying analytes mass spectrometrically, including applications in pharmaceutics and the analysis of compounds with potential adverse health effects. Furthermore, it explores the use of stochastic dynamic mass spectrometric theory for both quantitative analysis in condensed phases and 3D molecular structural analysis, emphasizing the integration of quantum chemical diffusion parameters based on Arrhenius's equation and the correlation between theoretical predictions and experimental results. The chapter highlights the advantages of the stochastic dynamic theory and its model equations in advancing the state-of-the-art in quantitative and structural mass spectrometry.
CHAPTER 2: Stochastic dynamic single particle inductively coupled plasma mass spectrometric quantitative analysis of gold nanoparticles. This chapter focuses on the application of stochastic dynamic theory to hard ionization mass spectrometry, specifically using inductively coupled plasma mass spectrometry (ICP-MS) for the quantitative analysis of gold nanoparticles. It details the experimental methodology, including materials, methods, and chemometrics, employed in the study. The chapter presents and discusses the results obtained, demonstrating the capability of the stochastic dynamic equations to accurately quantify isotope metal ions within complex mixtures and matrix effects using ICP-MS. This chapter emphasizes the broader applicability of the theoretical framework presented in Chapter 1, demonstrating its power and versatility across diverse mass spectrometry techniques.
Keywords
Stochastic dynamics, mass spectrometry, soft ionization, hard ionization, quantitative analysis, structural analysis, 3D molecular structure, inductively coupled plasma mass spectrometry (ICP-MS), gold nanoparticles, Arrhenius equation, quantum chemical diffusion parameters, analyte quantification, matrix effects.
Frequently Asked Questions: Stochastic Dynamics Mass Spectrometric Method for Quantitative and 3D Structural Analyses
What is the main objective of this work?
The primary objective is to present a unified approach to quantitative and structural analysis using mass spectrometry, encompassing both soft and hard ionization methods. This is achieved through the application of stochastic dynamic theory and its associated model equations. The work aims to bridge the gap between different mass spectrometry techniques and make advanced methodologies accessible to a wider audience.
What are the key themes explored in this work?
Key themes include the application of stochastic dynamic mass spectrometric theory and its applications; quantitative analysis of analytes in various matrices using mass spectrometry; determination of 3D molecular and electronic structures via mass spectrometry; application of stochastic dynamics to both soft and hard ionization mass spectrometry; and bridging the gap between soft and hard ionization techniques in quantitative and structural mass spectrometry.
What are the contents of Chapter 1?
Chapter 1 serves as an introductory review, providing an overview of quantitative and structural stochastic dynamics mass spectrometric approaches, primarily focusing on soft ionization methods. It details the theoretical concepts behind quantifying analytes mass spectrometrically, including applications in pharmaceutics and the analysis of compounds with potential adverse health effects. It explores the use of stochastic dynamic mass spectrometric theory for both quantitative analysis in condensed phases and 3D molecular structural analysis, emphasizing the integration of quantum chemical diffusion parameters based on Arrhenius's equation and the correlation between theoretical predictions and experimental results. The chapter highlights the advantages of the stochastic dynamic theory and its model equations in advancing the state-of-the-art in quantitative and structural mass spectrometry.
What is the focus of Chapter 2?
Chapter 2 focuses on the application of stochastic dynamic theory to hard ionization mass spectrometry, specifically using inductively coupled plasma mass spectrometry (ICP-MS) for the quantitative analysis of gold nanoparticles. It details the experimental methodology, including materials, methods, and chemometrics, employed in the study. The chapter presents and discusses the results obtained, demonstrating the capability of the stochastic dynamic equations to accurately quantify isotope metal ions within complex mixtures and matrix effects using ICP-MS. This chapter emphasizes the broader applicability of the theoretical framework presented in Chapter 1, demonstrating its power and versatility across diverse mass spectrometry techniques.
What are the key words associated with this work?
Key words include Stochastic dynamics, mass spectrometry, soft ionization, hard ionization, quantitative analysis, structural analysis, 3D molecular structure, inductively coupled plasma mass spectrometry (ICP-MS), gold nanoparticles, Arrhenius equation, quantum chemical diffusion parameters, and analyte quantification, matrix effects.
What types of mass spectrometry are discussed?
The work discusses both soft and hard ionization mass spectrometry techniques. Specific examples include inductively coupled plasma mass spectrometry (ICP-MS).
What is the significance of the stochastic dynamic theory in this context?
The stochastic dynamic theory provides a unified theoretical framework for both quantitative and structural analysis using mass spectrometry, regardless of the ionization method used (soft or hard). Its application allows for a more comprehensive and accurate analysis of analytes and their structures.
What types of applications are covered?
Applications covered include quantitative analysis of pharmaceuticals and compounds potentially causing adverse health effects, quantitative analysis of gold nanoparticles using ICP-MS, and 3D molecular structural analysis.
- Quote paper
- Prof. Dr. Bojidarka Ivanova (Author), Prof. Michael Spiteller (Author), 2023, Stochastic Dynamics Hard- and Soft-Ionization Mass Spectrometry, Munich, GRIN Verlag, https://www.grin.com/document/1335649
